One-way analysis of variance (ANOVA) with repeated measurements showed a significant decrease in BMD in the C group ( P < 0.001). There were no significant differences in age, body mass index, years since menopause, and initial BMD among the four groups. BMD of the lumbar spine (L2–L4) was measured by dual energy X-ray absorptiometry at 0, 1, and 2 years after the treatment started. Ninety-two osteoporotic women who were more than 5 years after menopause, aged 55–81 years, were randomly divided into four administration groups: vitamin D 3 (1α hydroxyvitamin D 3, 0.75 μg/day) (D group n = 29), vitamin K 2 (menatetrenone, 45 mg/day) (K group n = 22), vitamin D 3 plus vitamin K 2 (DK group, n = 21), and calcium (calcium lactate, 2 g/day) (C group n = 20).
The effect of the combined administration of vitamin D 3 and vitamin K 2 on bone mineral density (BMD) of the lumbar spine was examined in postmenopausal women with osteoporosis.
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